PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2010 July; 1(1): e0003. ISSN: 2076-9172Published online 2010 July 2. doi: 10.5041/RMMJ.10003.

Table 1.

Drugs used in treatment of Parkinson’s disease.

Dopamine replacement therapy	L-dopa + peripherally acting decarboxylase inhibitor (carbidopa, benserazide)
Direct dopamine agonists	Ropinirole, rotigotine, bromocriptine, pergolide, cabergoline, pramipexole, apomorphine
MAO-B inhibitors	Rasagiline, selegiline
COMT inhibitors	Entacapone^*, tolcapone^†
Antimuscarinic, DAT inhibitor	Benztropine^‡, trihexiphenidyl
NMDA receptor antagonists^§	Amantadine, memantine

MAO denotes monoamine oxidase, DA dopamine, DAT plasma membrane dopamine transporter.NET plasma membrane noradrenaline transporter, COMT catechol O-methyl transferase, and L-dopa, 3,4-dihydroxyphenylalanine.

^* Peripherally acting inhibitor.

^† Peripherally + centrally acting inhibitor.

^‡ Also inhibits DA uptake via plasma membrane DA transporter.

^§ Glutamate antagonists, moderate efficacy in Parkinsonism and L-dopa-induced dyskinesias.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2010 July; 1(1): e0003. ISSN: 2076-9172

Published online 2010 July 2. doi: 10.5041/RMMJ.10003.