Table 2.

Monoamine oxidase (MAO) subtypes, their substrates and inhibitors and cellular localization.

Selective inhibitors (irreversible, covalent combination with enzyme active site) Clorgyline Selegiline (deprenyl), rasagiline
Selective inhibitors (reversible, competitive inhibition) Moclobemide Lazabemide
Non-selective inhibitors Phenelzine, tranylcypromine
Selective substrates 5-HT, noradrenaline, adrenaline β-phenylethylamine, benzylamine
Mixed substrates Dopamine, tyramine
Cellular localization Sympathetic neurons, noradrenergic, dopaminergic and other neurons in CNS, placenta, GI tract, hepatocytes and many other cell types Astrocytes, platelets, many other peripheral cell types, serotonergic neuronal cell bodies in raphe nuclei
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2010 July; 1(1): e0003. ISSN: 2076-9172
Published online 2010 July 2. doi: 10.5041/RMMJ.10003.