An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is rmmj-2-1_e0019_Figure4.jpg

Figure 4.

A chemically modified, non-anticoagulant heparin is a potent inhibitor of heparanase enzymatic activity and melanoma lung colonization. Structure (top) and favored 3D conformation (bottom) of heparanase inhibitor 2 (HI-2) = heparin that is glycol-split (denoted by red circle) and N-acetylated (denoted by the blue circle). The enhanced flexibility of glycol-split heparin facilitates tight binding to heparanase (Hepa, bottom, left), resulting in potent inhibition of the enzyme activity and melanoma lung colonization (bottom, right).

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2011 January; 2(1): e0019. ISSN: 2076-9172
Published online 2011 January 31. doi: 10.5041/RMMJ.10019.