Endothelial dysfunction (diabetes, hypertension, atherosclerosis, tobacco use).
Endothelial dysfunction (diabetes, hypertension, atherosclerosis, tobacco use).
| Elevated asymmetric dimethyl arginine (ADMA) |
| Elevated reactive oxygen species (ROS) |
| Decreased NOS co-factors |
| Decreased NOS activity |
| Decreased NO production |
| Increased peroxynitrite formation with increased removal of NO |
| Possible role of L-arginine and anti-oxidant supplements |