Table 1.

GWAS for common diseases and traits.

Phenotype Number of GWAS loci Proportion of heritability explained (%) *
Type 1 diabetes 41 ∼60
Fetal hemoglobin levels 3 ∼50
Macular degeneration 3 ∼50
Type 2 diabetes 39 20–25
Crohn’s disease 71 20–25
LDL and HDL levels 95 20–25
Height 180 ∼12
* Fraction of heritability explained is calculated by dividing the phenotypic variance explained by variants at loci identified by GWAS by the total heritability as inferred from epidemiological parameters. Table included with permission (Lander ES. Nature 2011;470:193).4 HDL, high-density lipoprotein; LDL, low-density lipoprotein.
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2011 July; 2(3): e0053. ISSN: 2076-9172
Published online 2011 July 31. doi: 10.5041/RMMJ.10053.
Copyright : © 2011 Alan L. Schwartz.