Table 2.

Results of the randomized TRITON-TIMI 38 study. At 15 months, the primary efficacy end-point, a combination of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke, was reached in favor of prasugrel. The key safety end-point, non-CABG-related TIMI major bleeding, is also listed (in STEMI not significant). For more details, please see text.

Clopidogrel total (n= 6795) Prasugrel total (n= 6813) Clopidogrel STEMI (n= 1765) Prasugrel STEMI (n= 1769) Clopidogrel NSTE-ACS (n= 5030) Prasugrel NSTE-ACS (n= 5044)
Primary end-point 12.1% 9.9%* 12.4% 10.0%* 12.1% 9.9%*
Total mortality 3.2% 3.0% 4.3% 3.3% 2.4% 2.6%
Non-fatal myocardial infarction 9.5% 7.3%* 9.0% 6.8%* 9.8% 7.5%*
Stent thrombosis 2.4% 1.1%* 2.8 1.6* 2.2% 1.0%*
TIMI major bleeding 1.8% 2.4%* 2.1% 2.4% 1.6% 2.4%*
* P < 0.05.
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2011 July; 2(3): e0056. ISSN: 2076-9172
Published online 2011 July 31. doi: 10.5041/RMMJ.10056.