Table 1.

Phase II data—diffuse large cell lymphoma.

In the early 1980s, multiple new “improved” regimens.

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Many considered CHOP to be “unethical.”

COP-BLAM, cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin, and procarbazine; m-BACOD, bleomycin, doxorubicin, cyclophosphamide, vincristine, dexamethasone, methotrexate, and leucovorin; M-BACOD, methotrexate (high-dose) (with citrovorum factor rescue), bleomycin, doxorubicin, cyclophosphamide, vincristine and dexamethasone; ProMACE–MOPP, prednisone, methotrexate, doxorubicin cyclophosphamide, etoposide, mechlorethamine, vincristine, and procarbazine; COP-BLAM III, cyclophosphamide, infusional vincristine, prednisone, infusional bleomycin, doxorubicin, and procarbazine; ProMACE-CytaBOM, cyclophosphamide, doxorubicin, cytarabine, bleomycin, vincristine, methotrexate, and prednisone; MACOP-B, methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2013 January; 4(1): e0004. ISSN: 2076-9172
Published online 2013 January 30. doi: 10.5041/RMMJ.10104.