PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2013 January; 4(1): e0004. ISSN: 2076-9172Published online 2013 January 30. doi: 10.5041/RMMJ.10104.

Table 4.

Controlled trials of growth factors after induction therapy in AML.

Study	n	Reduction in Days to ANC 1000/μL	Documented Reduced Morbidity

GM-CSF (sargramostim)
Büchner, 1991	86	6–9	+
Rowe, 1995	117	6	+
GM-CSF (molgrastim)
Stone, 1995	379	2
Zittoun, 1996	53	-
Lowenberg, 1997	316	5
Witz, 1998	209	6
Löfgren, 2004	110	8
G-CSF (lenograstim)
Dombert, 1995	173	6	+
Link, 1996	187	6	+
Goldstone, 2001	803	5
Amadori, 2005	722	5	+
G-CSF (filgrastim)
Ohno, 1990	67	12	+
Ohno, 1994	58	6
Heil, 1997	521	5	+
Godwin, 1998	234	3–4	+
Usuki, 2002	270	6	+
Lehrnbecher, 2007	317	5
Estey, 1994	197	13

Published with permission from Rowe JM and Avivi I.¹⁹

ANC, absolute neutrophil count; G-CSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte-macrophage colony-stimulating factor.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2013 January; 4(1): e0004. ISSN: 2076-9172

Published online 2013 January 30. doi: 10.5041/RMMJ.10104