Table 2.

Different Types of Synthetic Polymers Used in the Research Field of the Right Ventricular Outflow Tract.

PolymerCell TypeAnimal ModelRef.
Poly(ethylene glycol) (PEG)Human MSC, valvular interstitial cells (VIC)n.a.8791
Poly(glycolic acid) (PGA)/Poly(lactic acid) (PLA)
  • Fibroblasts, epithelial cells (EC) and ovine VIC
  • Human fibroblasts, bovine aortic EC
lambs (2 weeks)92, 93
PGA/Poly-4-hydroxybutyrate (P4HB)
  • Myofibroblasts, ovine EC
  • Stem cells, endothelial progenitor cells, and ovine valvular endothelial cells (VEC)
lambs (20–100 weeks)9498

  • Human amniotic fluid-derived stem cells
sheep (8 weeks)
Polycaprolactone (PCL)Human myofibroblastsn.a.99
Poly(glycerol sebacate) (PGS)/PCLHuman umbilical vein-derived endothelial cells (HUVEC)n.a.100
Poly(ester urea urethane) (PEUU)Smooth muscle cells (SMC) from ratsn.a.101104
Polydioxaneone (PDO)Ovine MSClambs (1, 4, 8 months)105
Polycarbonate PCU–Polyhedral oligomeric silsesquioxanes (POSS)n.a.n.a.106

n.a.=not applicable

Rambam Maimonides Med JRambam Maimonides Medical JournalRambam Health Care Campus 2013 July; 4(3): e0019. ISSN: 2076-9172
Published online 2013 July 25. doi: 10.5041/RMMJ.10119