Studies Addressing the Impact of Margins Status on Local Control in TLM for Glottic Cancer
Studies Addressing the Impact of Margins Status on Local Control in TLM for Glottic Cancer
| Author | Patients | T Stage | Adequate Margin Definition | Use of Frozen Section | Inadequate or Positive Margins on Final Pathology | Further Treatment for Inadequate or Positive Margins (Number of Patients; Treatment) | Rate of Positive Pathology on Second Resection | Rate of Local Recurrence in Inadequate or Positive Margins | Rate of Local Recurrence in Negative Margins | Significant Impact of Margins Status on Local Control | Initial Local Control Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Fang17 (2013) | 75 | T1, T2 | NA | yes | I: 10 (10%) P: 28 (40%) |
none | 18% | 3% | no | 84% | |
| Michel10 (2011) | 64 | T1 | 1–2 mm | no | 24 (37.5%) | 10; re-resection | 10% | 17% | 5% | no | 91% |
| Peretti19 (2010) | 595 | Tis-T3 | >1 mm | no | 300 (50%) | 71; re-resection | 14% | 7%–15% | 6% | yes | 85% |
| Ansain18 (2009) | 274 | Tis-T1 | >1 mm | no | I: 40 (15%) P: 54 (20%) |
28; RT 36; re-resection |
8% | 14% | 2% | yes | 91% |
| Hartl9 (2008) | 79 | Tis-T1 | >2 mm | no | I: 20 (25%) P: 5 (6%) |
3; resection | 0 | 24% | 9% | no | 96% |
| Manola11 (2008) | 31 | T1 | 1–2 mm | no | 3 (10%) | 3; resection | 0 | 3% | 0 | no | 95% |
| Brondbo8 (2007) | 171 | T1 | 1–2 mm | no | 62 (36%) | none | 14.5% | 4% | no | 91% | |
| Crespo20 (2006) | 40 | T1, T2 | NA | yes | P: 8 (20%) | 2; RT | 37.5% | 0 | yes | 93% |