Table 1.

Clinical and Pathological Comparison of Spermatocytic Variant of Classic Seminoma (SVCS) with Classic Seminoma (CS).

Spermatocytic Seminoma Classic Seminoma
CLINICAL
1. Site of origin Testis only Testis, ovary, retroperitoneum, central nervous system (midline structures)
2. Arise in cryptorchid testes No 10%
3. Age (years): mean (range) 54 (25–87) 41 (childhood to 85+)
4. Fraction of testis involved by tumor 2% 40%
5. Associated other germ cell tumor types None Common
6. Association with sarcoma of testis 5% None
MICROSCOPIC PATHOLOGY
1. Cell size Small, medium, large Medium
2. Nuclei Spherical Irregular
3. Cytoplasm Eosinophilic to amphophilic Pale to clear
4. Cytoplasmic glycogen Absent Abundant
5. Edema fluid Often present Absent
6. Lymphocytic infiltrate Sparse to absent Prominent
7. Syncytiotrophoblast None Occasional
8. Granulomas None Occasional
9. Lymphocyte-rich fibrovascular septae Absent Present
10. Associates intratubular germ cell tumor None Common
11. Microcystic pseudoglandular formation Present Absent
MOLECULAR BIOLOGY/IMMUNOHISTOCHEMISTRY
1. Placental alkaline phosphatase staining Rarely Strong, diffuse
2. CD-117 staining Absent Present
3. Cytokeratin 18 Absent Present
4. S-phase fraction Twice as great as classic seminoma
5. DNA content <3N >3N
6. Gene overexpression chromosome 9 Positive Negative
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2014 July; 5(3): e0021. ISSN: 2076-9172
Published online 2014 July 25. doi: 10.5041/RMMJ.10155