ADAMTS-13 Domain Structure.

ADAMTS-13 N-terminal composed of a signal peptide and propeptide, which are cleaved during the protein processing. The catalytic domain consists of the metalloprotease and disintegrin domains. A first thrombospondin-1 (TSP 1) is followed by a cysteine-rich domain (Cys), a spacer, and sevenadditional TSP 1 repeats (TSP 2–8). The C terminus contains two complement components C1r/C1s, embryonic sea urchin protein, and bone morphogenic protein-1(CUB) domains.