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Figure 1.   Mechanisms of Treg-mediated Immune Suppression

Treg suppress immune responses through molecular pathways that act directly on T cells or indirectly through antigen-presenting cells such as dendritic cells. These molecular mechanisms are described in Table 1. FGL2 binds to FcγRIIB on dendritic cells to inhibit dendritic cell maturation. DC, dendritic cell; IL-2R, IL-2 receptor; Teff, effector T cell; Treg, regulatory T cell.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2015 July; 6(3): e0024. ISSN: 2076-9172
Published online 2015 July 30. doi: 10.5041/RMMJ.10209