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Figure 4.   Differentially Expressed Treg-related Genes in Cardiac Allografts Serve as Putative Biomarkers of Tolerance

Graphs display differentially expressed genes between tolerant (□) and rejecting (●) grafts from a panel of 22 Treg-related genes as assessed by multiplex RT-PCR. The expression of a gene was normalized to the housekeeping gene hypoxanthine phosphoribosyl transferase, and expression was then calculated as a ratio compared with the expression in non-transplanted hearts. Three allografts were used for each time point for both tolerant and rejecting groups. Graph shows mean±SEM. *P<0.05 versus rejecting group at the same time point. Copyright (2014) John Wiley and Sons. Used with permission from Urbanellis P, Shyu W, Khattar R, et al.49

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2015 July; 6(3): e0024. ISSN: 2076-9172
Published online 2015 July 30. doi: 10.5041/RMMJ.10209