An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is rmmj-6-3-e0024-g005.jpg

Figure 5.   Potential Therapeutics Targeting the FGL2–FcγRIIB Pathway

There are three main approaches currently being pursued to modulate the FGL2–FcγRIIB pathway for clinical benefit: (1) development of rFGL2 (monomeric and oligomeric) to inhibit immune responses; (2) expansion of TIGIT+ Treg expressing high levels of FGL2, which would represent a cellular therapy for transplantation and autoimmune disease; and (3) development of anti-FGL2 monoclonal antibodies to inhibit FGL2 signaling and enhance immune responses in cancer and chronic infections. DC, dendritic cell; PVR, poliovirus receptor; rFGL2, recombinant FGL2; TIGIT, T cell immunoreceptor with Ig and ITIM domains; Treg, regulatory T cell.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2015 July; 6(3): e0024. ISSN: 2076-9172
Published online 2015 July 30. doi: 10.5041/RMMJ.10209