Unmet Need: Percutaneous, Minimally Invasive Treatment for Aortic Stenosis–Time Frame of Development of the First Disruptive Device.
Unmet Need: Percutaneous, Minimally Invasive Treatment for Aortic Stenosis–Time Frame of Development of the First Disruptive Device.
| Year | Event | Reference |
|---|---|---|
| 1985 | Aortic balloon angioplasty by Alain Cribier | Cribier et al.21 |
| 1989 | First successful experiment in pigs with porcine aortic valve in an expandable metal cage; published in 1992 | Andersen et al.22 |
| 1990 | Priority date for the Andersen patent granted in 1995 | Andersen et al.23 |
| 1999 | PVT founded and acquired rights of the Anderson patent | Datafox24 |
| 2002 | First human implantation by Alain Cribier | Cribier et al.25 |
| 2004 | PVT acquired by Edwards | Bloomberg Business26 |
| 2005 | Edwards Feasibility trial launched | Barbash and Waksman27 |
| 2006 | Initiating the pivotal FDA study–PARTNERS | Barbash and Waksman27 |
| 2007 | CE approval granted in Europe for the Sapien™ valve | Barbash and Waksman27 |
| 2008 | The Sapien™ valve approved in Israel | Segev and Goita28 |
| 2010 | The Sapien™ valve granted public funding for non-operable surgical patients | The Prime Minister’s Office29 |
| 2011 | FDA approval for non-operable patients | Barbash and Waksman27 |