Table 2.

Comparison between NNT Computed from the Incidence Rate of Liver Failure Per Patient-Year with That from More Proper Cumulative Incidence Based on the Kaplan–Meier Approach for the Hypothetical Three-arm 1-Year Trial of 3,000 Patients with the (Imaginary) Iron Overload Syndrome.

Using Kaplan–Meier Approach Using Simple Rate Per Patient-year
Treatment Number of Patients Number of Patient-years Number with Liver Failure 1-Year Cumulative Incidence Number Needed to Treat Incidence Rate Per Patient Per Year Number Needed to Treat
Placebo 1000 549.8 324 0.454 0.589

Fedom 1000 576.2 230 0.286 6 0.399 6

Feclad 1000 615.7 238 0.441 77 0.387 5
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2015 July; 6(3): e0033. ISSN: 2076-9172
Published online 2015 July 30. doi: 10.5041/RMMJ.10218