Table 2.

Multisystemic Nature of EDS-HT.

System Manifestations
Cardiovascular Aortic regurgitation, aortic root dilatation, mitral valve prolapse, mitral regurgitation, tricuspid regurgitation, Reynaud phenomenon
Autonomic Nervous System Palpitations, dizziness, pre-syncope, syncope
Gastrointestinal Gastroesophageal reflux, dyspepsia, gastritis, delayed gastric emptying, irritable bowel syndrome
Hematologic Easy bruising, bleeding tendency, prolonged bleeding time, oral mucosal bruises, menometrorrhagia
Ocular Myopia, strabismus
Gynecologic Dysmenorrhea, menorrhagia, dyspareunia, uterine prolapse
Urologic Constipation, fecal soiling, urinary tract infections, urinary incontinence, bladder prolapse, rectal prolapse,
Obstetric Short labor and delivery, premature rupture of membranes, pelvic pain, varicose veins, worsening of dysautonomia during pregnancy, postpartum hemorrhage, complicated perineal wounds
Neurologic Headache, local anesthesia failure, postural instability, increased frequency of falls, impaired proprioceptive acuity, Chiari 1 type 1
Psychiatric Kinesiophobia, anxiety, depression
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2016 October; 7(4): e0034.
Special Issue on Rheumatology Guest Editor: Alexandra Balbir-Gurman, M.D.
ISSN: 2076-9172
Published online 2016 October 31. doi: 10.5041/RMMJ.10261.