An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is rmmj-10-2-e0012-g002.gif

Figure 2.

Risk Stratification, Preventive Therapy, and Surveillance of Trastuzumab-treated Patients.

Blue arrows symbolize cardio-oncological chronological point of intervention.

*Dependent on the availability of alternative therapies and following cardio-oncology team discussion. Holding trastuzumab and re-challenge following EF normalization (LVEF>50%) is one potential strategy. LVEF should be assessed using 2D Simpson’s LVEF or preferably 3D-based LVEF. One risk stratification criterion required. §dLVEF>10%: reduction in LVEF>10% and LVEF<50%.

AC, anthracyclines; dLVEF, difference in left ventricular ejection fraction; EF, ejection fraction; GLS, global longitudinal strain; HsTnI, high-sensitivity troponin I; LV, left ventricular; RT, radiation therapy.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2019 April; 10(2): e0012. ISSN: 2076-9172
Published online 2019 April 18. doi: 10.5041/RMMJ.10366.