Table 1.

Risk Factors for Anthracycline Cardiotoxicity.5,2831

Risk Factor
Compromised cardiac function (e.g. borderline low LVEF [50% to 55%], history of myocardial infarction, ≥moderate valvular heart disease) at any time before or during treatment
Older age (≥60 years) at cancer treatment
Female gender
Multiple cardiovascular risk factors (≥two risk factors)
Concomitant agents: trastuzumab, cyclophosphamide, paclitaxel
High-dose radiation therapy (≥30 Gy) where the heart is in the treatment field
Combination with alkylating or antimicrotubule chemotherapeutics
Young age (<5 years) at cancer treatment, especially girls
Renal failure
Genetic factors (trisomy 21, hereditary hemochromatosis, African-American ancestry)
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2019 April; 10(2): e0012. ISSN: 2076-9172
Published online 2019 April 18. doi: 10.5041/RMMJ.10366.