Table 1.

Changes in View and Management of Depression in Young Persons.

Date/Time Period Stance and Management
1970s Childhood depression considered non-existent1
1990s Childhood depression undisputed1,5153
Since 1997
  • FDA rewards 23 placebo-controlled pediatric studies to test efficacy of antidepressants in “children”
  • The United States Treatment of Adolescents with Depression Study (TADS) is nationally funded
  • Pediatric antidepressant efficacy studies with mixed results1,5459
  • FDA issues black-box warning for antidepressants in children, adolescents, and young adults because of their association with suicidality
  • Studies referenced by FDA not designed to assess suicidality58,59
  • Decrease in prescriptions for SSRIs and antidepressants in young patients, and increased incidence of suicide58,59
  • Fluoxetine the only antidepressant FDA-approved in “children”60,61
2009 FDA approves escitalopram for major depressive disorder (MDD) in “children”62
To date Academic researchers continue to accept the division into adult versus “pediatric” populations; they perform studies, analyses, meta-analyses, and demand more research6367
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2019 July; 10(3): e0018. ISSN: 2076-9172
Published online 2019 July 18. doi: 10.5041/RMMJ.10371.