PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2019 July; 10(3): e0018. ISSN: 2076-9172Published online 2019 July 18. doi: 10.5041/RMMJ.10371.

Date/Time Period	Stance and Management
1970s	Childhood depression considered non-existent¹
1990s	Childhood depression undisputed¹^,⁵¹^–⁵³
Since 1997	FDA rewards 23 placebo-controlled pediatric studies to test efficacy of antidepressants in “children” The United States Treatment of Adolescents with Depression Study (TADS) is nationally funded Pediatric antidepressant efficacy studies with mixed results¹^,⁵⁴^–⁵⁹
2004	FDA issues black-box warning for antidepressants in children, adolescents, and young adults because of their association with suicidality Studies referenced by FDA not designed to assess suicidality⁵⁸^,⁵⁹ Decrease in prescriptions for SSRIs and antidepressants in young patients, and increased incidence of suicide⁵⁸^,⁵⁹ Fluoxetine the only antidepressant FDA-approved in “children”⁶⁰^,⁶¹
2009	FDA approves escitalopram for major depressive disorder (MDD) in “children”⁶²
To date	Academic researchers continue to accept the division into adult versus “pediatric” populations; they perform studies, analyses, meta-analyses, and demand more research⁶³^–⁶⁷