Table 1.

Weighted ASD Diagnostic Power for Each Evaluated Modality.

Modality Sensitivity (%) Specificity (%) Overall Agreement (%) Area under Curve (AUC) (%)
Genetic
 Pool 79.3 73.1 76.7 79.5
 Range 24.3–100 41.8–88.2 62.7–90.4 64.8–92.0
 95% CI 73.3–84.7 69.6–76.5 73.8–79.5 77.0–82.0
I2 87.5 56.9 70.8 52.5

MRI
 Pool 73.6 73.0 73.5 79
 Range 43.7–94.8 45.4–100 57.9–95.7 58.0–99.5
 95% CI 71.8–76.0 70.0–76.0 71.0–75.9 75.0–83.0
I2 78.1 84.4 89.1 96.4

Metabolic
 Pool 74.6 85.9 83.3 88.3
 Range 0–100 15.0–100 48.7–100 59.2–99.9
 95% CI 66.8–81.6 82.7–88.7 80.3–86.1 86.0–91.0
I2 97.7 87.1 ND 92.2

Protein
 Pool 85.5 84.7 83.8 89.5
 Range 50–100 38.9–100 62.8–100 57.0–99.9
 95% CI 80.0–90.3 78.6–90 81.0–86.5 86.0–93.0
I2 87.3 89.2 73 90.1

EEG
 Pool 79.9 80.4 79.9 ND
 Range 57.6–90.9 64.5–100 70.5–87.4 ND
 95% CI 70.5–87.9 73.3–86.6 73.5–85.5 ND
I2 83.4 79.5 85.2 ND

ND, not done.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2019 October; 10(4): e0021. ISSN: 2076-9172
Published online 2019 October 29. doi: 10.5041/RMMJ.10375.