Cannabis/Cannabinoids Administration to Syngeneic Bone Marrow Transplantation Model.

A: Recipient C57BL/6 mice (R) received lethal whole-body irradiation and were reconstituted with 8×10⁶ donor C57BL/6 (D) bone marrow cells. Cannabis/cannabinoids were administered IP every other day, for 2 weeks from the day of transplantation. Blood samples for complete blood counts were obtained once a week. B: Lymphocyte counts (day 21 after transplantation) in pure cannabinoid-treated groups (left) and BDS-treated groups (right) are presented. C: Platelet counts in pure cannabinoid-treated groups (left) and BDS-treated groups (right), day 14 after transplantation. * P<0.05; ** P<0.001; *** P<0.0001. Modified from Figure 4 in Khuja et al.¹⁷; reused under creative commons license (CC BY 4.0).

BDS, botanical drug substance; BMT, bone marrow transplantation; IP, intraperitoneally; THC, Δ9-tetrahydrocannabinol.