Figure 2.
The Role of CB2 in Lymphocyte Recovery.
A: Syngeneic BMT from CB2 KO donor mice to C57BL/6 WT mice. Average lymphocyte counts at different time points (left) and counts on day 21 after transplantation (right). *** P<0.0001. B: Syngeneic BMT from C57BL/6 WT donor mice to CB2 KO mice. Average lymphocyte counts at different time points (left) and counts on day 21 after transplantation (right). C: Model: CB2 has an inhibitory effect on post-transplant rehabilitation of blood lymphocytes. The WT graft rehabilitation will be delayed by endo- (ECS) and/or phyto-cannabinoid (THC) signaling (red T-bars) through CB2. Since the knockout graft does not express CB2, this inhibition is removed. Modified from Figure 5 in Khuja et al.17; reused under creative commons license (CC BY 4.0).
BMT, bone marrow transplantation; ECS, endocannabinoids; CB2 KO, CB2 knockout; THC, Δ9-tetrahydrocannabinol; WT, wild type.