Comparison of the COX-1 and COX-2 Isoforms.
Comparison of the COX-1 and COX-2 Isoforms.
| Parameter | COX-1 Isoform | COX-2 Isoform |
|---|---|---|
| Style of expression | Constitutive | Inducible |
|
| ||
| Location | Chromosome 9 | Chromosome 1 |
|
| ||
| Relative size of active site | Smaller | Larger |
|
| ||
| Size of gene | 22 kb | 8.3 kb |
|
| ||
| TATA box | - | + |
|
| ||
| Size of mRNA | 2.8 kb | 4.5 kb |
|
| ||
| Molecular weight | 70 kDa | 72 kDa |
| Number of amino acids | 576* | 581† |