PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2021 April; 12(2): e0016. ISSN: 2076-9172Published online 2021 April 29. doi: 10.5041/RMMJ.10438

Year	Lesions Included in Study	Factors Compared	Study Findings
2007¹³	Dysplasia Submucous fibrosis OLP OSCC	MC count	MC increased in all the four conditions compared to normal oral mucosa
2008¹⁴	Dysplasia OSCC	MCD MVD	MVD and MCD seem to be significantly ↑ from normal oral tissues through leukoplakia with various degrees of dysplasia to OSCC
2010¹⁵	OLP	MCD	MCD in lichen planus ↑ when compared to NOM MC were significantly ↑ below the inflammatory band, and MC degranulation was also found to be prominent
2010¹⁶	OSCC	MC count MVD	MC count and MCD significantly increased from normal to OSCC
2011¹⁷	OLP	In vitro to in vivo methods compared to evaluate angiogenetic phenomenon	Neoangiogenesis occurs in OLP
2011¹⁸	OLP Oral lichenoid reaction	MC count	MC count ↑ in OLP and OLR in comparison to NOM
2012¹⁹	Different grades of dysplasia Different grades of dysplasia OSCC	MCD	VEGF and MVD increased with disease progression and were statistically higher in oral OSCC than in epithelial dysplasia and NOM
2012⁹	OSCC	MCD MVD	Significant difference between mean MCD and MVD values in normal mucosa and OSCC, no positive correlation observed between MCD and MVD values in OSCC
2012²⁰	OLP Oral lichenoid lesions	Number of MC Thickness of epithelium and basement membrane	Number of degranulated MC in reticular layer of corium in lichenoid lesions greater than that of OLP
2012²¹	OLP	MVD	Significant angiogenesis ↑ in OLP as compared to NOM, and in erosive OLP as compared to reticular OLP
2012²²	OLP Oral lichenoid mucositis	Number of intact MC and degranulated MC Number of capillaries Number of eosinophils	Significant ↑ in number of MC in OLP and oral lichenoid mucositis compared to NOM Significant ↑ of intact MC subepithelially within inflammatory cell infiltrate in OLP compared to oral lichenoid mucositis Significant ↑ of degranulated MC, eosinophil densities, and number of capillaries in oral lichenoid mucositis compared to OLP
2012²³	NOM Different grades of dysplasia	MCD MVD	Exponential ↑ in MVD as MCD ↑ as it progresses from NOM to dysplasia
2013²⁴	OSCC Verrucous carcinoma	MCD MVD	Significant correlation in mean MVD and mean MCD in well differentiated OSCC No significant correlation in other carcinoma grades and normal tissue
2015²⁵	NOM Dysplasia OSCC	MCD MVD	MCs and MVs ↑ from NDL to DL to OSCC with the exception that MVD was slightly higher in NOM group than in NDL; this difference was not statistically significant Poor correlation between MVD and MCD
2015²⁶	NOM Dysplasia OSCC	MCD MVD	MCD and MVD ↑ in oral epithelial dysplasia and in OSCC compared to NOM
2016²⁷	OSCC	MCD MVD	Significant correlation found between MCD and MVD
2017²⁸	NOM Oral leukoplakia (without and with dysplasia) OSCC	MCD MVD	MVD and MCD significantly ↑ in OSCC cases as compared to leukoplakia with and without dysplasia and normal gingival tissue
2018²	OSCC	MCD MVD	Significant correlation between MCD and MVD in OSCC; both are significantly ↑ in disease process compared to that of NOM
2018²⁹	NOM Dysplasia OSCC	MC count	Highly significant ↑ of MC in oral epithelial dysplasia compared to OSCC Significant ↑ in MC in OSCC compared to NOM
2018³⁰	OLP OLR	MC count	MC count ↑ in OLP and OLR compared to NOM
2019³¹	OLP	MVD	Vascular density ↑ in OLP could be result of angiogenesis phenomenon, and mediators of angiogenesis are potential markers for lesion progrssion toward dysplastic changes