Table 1.

Summary of Published Series Reporting the Role of Mast Cells and Microvessels in Various Oral Lesions.

Year Lesions Included in Study Factors Compared Study Findings
200713
  • Dysplasia
  • Submucous fibrosis
  • OLP
  • OSCC
MC count MC increased in all the four conditions compared to normal oral mucosa
200814
  • Dysplasia
  • OSCC
  • MCD
  • MVD
MVD and MCD seem to be significantly ↑ from normal oral tissues through leukoplakia with various degrees of dysplasia to OSCC
201015
  • OLP
MCD MCD in lichen planus ↑ when compared to NOM
MC were significantly ↑ below the inflammatory band, and MC degranulation was also found to be prominent
201016 OSCC
  • MC count
  • MVD
MC count and MCD significantly increased from normal to OSCC
201117 OLP In vitro to in vivo methods compared to evaluate angiogenetic phenomenon Neoangiogenesis occurs in OLP
201118
  • OLP
  • Oral lichenoid reaction
MC count MC count ↑ in OLP and OLR in comparison to NOM
201219
  • Different grades of dysplasia
  • Different grades of dysplasia OSCC
MCD VEGF and MVD increased with disease progression and were statistically higher in oral OSCC than in epithelial dysplasia and NOM
20129 OSCC
  • MCD
  • MVD
Significant difference between mean MCD and MVD values in normal mucosa and OSCC, no positive correlation observed between MCD and MVD values in OSCC
201220
  • OLP
  • Oral lichenoid lesions
  • Number of MC
  • Thickness of epithelium and basement membrane
Number of degranulated MC in reticular layer of corium in lichenoid lesions greater than that of OLP
201221 OLP MVD Significant angiogenesis ↑ in OLP as compared to NOM, and in erosive OLP as compared to reticular OLP
201222
  • OLP
  • Oral lichenoid mucositis
  • Number of intact MC and degranulated MC
  • Number of capillaries
  • Number of eosinophils
Significant ↑ in number of MC in OLP and oral lichenoid mucositis compared to NOM
Significant ↑ of intact MC subepithelially within inflammatory cell infiltrate in OLP compared to oral lichenoid mucositis
Significant ↑ of degranulated MC, eosinophil densities, and number of capillaries in oral lichenoid mucositis compared to OLP
201223
  • NOM
  • Different grades of dysplasia
  • MCD
  • MVD
Exponential ↑ in MVD as MCD ↑ as it progresses from NOM to dysplasia
201324
  • OSCC
  • Verrucous carcinoma
  • MCD
  • MVD
Significant correlation in mean MVD and mean MCD in well differentiated OSCC
No significant correlation in other carcinoma grades and normal tissue
201525
  • NOM
  • Dysplasia
  • OSCC
  • MCD
  • MVD
MCs and MVs ↑ from NDL to DL to OSCC with the exception that MVD was slightly higher in NOM group than in NDL; this difference was not statistically significant
Poor correlation between MVD and MCD
201526
  • NOM
  • Dysplasia
  • OSCC
  • MCD
  • MVD
MCD and MVD ↑ in oral epithelial dysplasia and in OSCC compared to NOM
201627 OSCC
  • MCD
  • MVD
Significant correlation found between MCD and MVD
201728
  • NOM
  • Oral leukoplakia (without and with dysplasia)
  • OSCC
  • MCD
  • MVD
MVD and MCD significantly ↑ in OSCC cases as compared to leukoplakia with and without dysplasia and normal gingival tissue
20182 OSCC
  • MCD
  • MVD
Significant correlation between MCD and MVD in OSCC; both are significantly ↑ in disease process compared to that of NOM
201829
  • NOM
  • Dysplasia
  • OSCC
MC count Highly significant ↑ of MC in oral epithelial dysplasia compared to OSCC
Significant ↑ in MC in OSCC compared to NOM
201830
  • OLP
  • OLR
MC count MC count ↑ in OLP and OLR compared to NOM
201931 OLP
  • MVD
Vascular density ↑ in OLP could be result of angiogenesis phenomenon, and mediators of angiogenesis are potential markers for lesion progrssion toward dysplastic changes

DL, dysplastic lesion; MC, mast cell; MCD, mast cell density; MV, microvessel; MVD, microvessel density; NDL, non-dysplastic lesion; NOM, normal oral mucosa; OLP, oral lichen planus; OLR, oral lichenoid reaction; OSCC, oral squamous cell carcinoma.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2021 April; 12(2): e0016. ISSN: 2076-9172
Published online 2021 April 29. doi: 10.5041/RMMJ.10438.