Clinical and Biological Study Population Characteristics by PCSK9 Tertile.
Clinical and Biological Study Population Characteristics by PCSK9 Tertile.
| Variables | Overall
n=251 |
Tertile 1
n=84 |
Tertile 2
n=83 |
Tertile 3
n=84 |
P Value |
|---|---|---|---|---|---|
| SBP (mmHg) | 154.8±21.5 | 155.6±20.3 | 153.9±21.5 | 154.8±22.7 | 0.871 |
| DBP (mmHg) | 88.4±13.6 | 88.3±13.9 | 88.3±13.5 | 88.7±13.4 | 0.978 |
| MAP (mmHg) | 110.5±14.4 | 110.7±14.5 | 110.2±14.3 | 110.7±14.5 | 0.959 |
| PP (mmHg) | 66.4±17.7 | 67.4±16.4 | 65.6±17.7 | 66.2±18.9 | 0.801 |
| RP (ppm) | 89.4±13.8 | 89.7±13.9 | 88.9±14.4 | 89.8±13.3 | 0.917 |
| BMI (kg/m2 ) | 23.5±4.8 | 23.5±4.3 | 23.3±4.3 | 23.8±5.6 | 0.828 |
| HbA1c (%) | 7.1±3.1 | 5.7±0.5 | 8.2±4.3 | 6.5±1.2 | 0.291 |
| Hb (g/dL) | 8.5±1.9 | 8.2±1.7 | 8.6±1.9 | 8.9±2.0 | 0.048 |
| Creatine (mg/dL) | 10.2 (9.6–11.2) | 10.6 (9.4–12.0) | 9.9 (8.2–10.8) | 11.0 (9.4–13.8) | 0.629 |
| eGFR (mL/min/1.73 m2) | 6.0 (5.6–6.69) | 6.2 (5.6–7.2) | 6.7 (5.8–7.9) | 5.4 (4.6–6.9) | 0.609 |
| Urea (mg/dL) | 146.0 (131.8–163.5) | 154.1 (127.9–180) | 139.4 (116–153) | 155 (125.8–197) | 0.064 |
| Uric Acid (mg/dL) | 11.7±19.8 | 7.5±2.9 | 10.4±2.8 | 15.5±30.1 | 0.597 |
| TC (mg/dL) | 152.8±48.2 | 114.4±28.8 | 165.4±44.7 | 178.9±43.2 | <0.001 |
| HDL-c (mg/dL) | 40.3±22.1 | 52.0±27.4 | 37.6±18.9 | 31.1±11.9 | <0.001 |
| LDL-c (mg/dL) | 110.7±44.1 | 90.1±34.3 | 102.5±46.8 | 139.5±34.3 | <0.001 |
| TG (mg/dL) | 132.3±63.9 | 103.5±35.2 | 125.5±83.1 | 167.8±45.8 | <0.001 |
| tCa (mmol/L) | 2.3 (2.1–2.4) | 2.5 (2.1–2.8) | 1.9 (1.8–2.3) | 2.3 (2.0–2.7) | 0.489 |
| iCa (mmol/L) | 1.0 (0.9–1.03) | 1.0 (0.9–1.03) | 0.98 (0.89–1.03) | 0.99 (0.89–1.03) | 0.310 |
| Ph (mmol/L) | 2.2 (1.9–2.8) | 1.6 (1.3–2.1) | 2.0 (1.6–2.9) | 2.9 (2.6–2.95) | 0.219 |
| PTHi (ng/L) | 181.6 (123.5–192.3) | 184.4 (88.9–192.3) | 192.3 (98.4–192.3) | 177.4 (80.7–192.3) | 0.281 |
| Vitamin D (ng/L) | 52.2 (46.3–64.0) | 36.4 (28.7–49.9) | 38.5 (28.5–60.5) | 65.7 (65.4–65.7) | <0.001 |
| FM (%) | 27.0±9.3 | 27.8±9.1 | 26.6±9.5 | 26.6±9.5 | 0.661 |
| MM (%) | 25.7±8.4 | 24.6±8.3 | 25.3±7.4 | 26.9±9.4 | 0.183 |
BMI, body mass index; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FM, fat mass; Hb, hemoglobin; HbA1c, glycated hemoglobin; HDL-c, high-density lipoprotein cholesterol; iCa, ionized calcium; LDL-c, low-density lipoprotein cholesterol; MAP, mean arterial pressure; MM, muscular mass; Ph, phosphorus; PP, pulse pressure; PTHi, intact parathormone; RP, radial pulse; SBP, systolic blood pressure; TC; total cholesterol; tCa, total calcium; TG, triglycerides.