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Figure 1.

Diagrammatic Representation of Resorption Dynamics at the Biochemical Level.

The bone/root resorption process is similar at cellular levels for both osteoclasts and odontoclasts.8 Cellular differentiation from mononucleated (progenitor osteoclasts) to multinucleated (mature osteoclasts) involves pro-resorption and anti-resorption. The M-CSF is responsible for proliferation and differentiation of progenitor cells; proinflammatory cytokines are directly responsible for differentiation and activation of pre-osteoclasts, or activation of RANKL, which in turn leads to pro-resorptive gene expression (TRAP, etc.). Anti-resorptive OPG (decoy receptor for RANKL) and IL-1RA (receptor antagonist to IL-1β) govern the resorptive activity, with the RANKL/OPG ratio being the primary governing factor.

IL-1β, interleukin-1β; IL-1RA, interleukin-1 receptor antagonist; IL-6, interleukin 6; M-CSF, macrophage colony-stimulating factor; OPG, osteoprotegerin; PDL, periodontal ligament; RANKL, receptor activator of nuclear factor kappa-B ligand; TNF-α, tumor necrosis factor-α; TRAP, tartrate-resistant acid phosphatase.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2022; 13(4): e0027. ISSN: 2076-9172
Published online 2022 October 27. doi: 10.5041/RMMJ.10482