Main Proposed Mechanisms of How Mitochondria Influence the Pathophysiology of Idiopathic Inflammatory Myopathies.

AMA-M2, anti-mitochondrial antibodies against the E2 subunit of the 2-oxo acid dehydrogenase complex; ATP, adenosine triphosphate; DAMPs, damage-associated molecular patterns; DM, dermatomyositis; FGF-21, fibroblast growth factor 21; fMet, N-formylated methionine peptides; GDF-15, growth differentiation factor-15; IBM, inclusion-body myositis; IFN, interferon; IIM, idiopathic inflammatory myopathy; mtDNA, mitochondrial DNA; PBC, primary biliary cholangitis; SNPs, single nucleotide polymorphisms. Created with Biorender.com.