Table 1.

Family A: Demographics and Medical History of Affected Individuals.

Parameter Subject Number
I1 II1 III1 III2 III3 III4 IV1
Sex F F F F F F F
Age at onset (years) 40 40 22 18 37 32 25
Eye involved BE BE BE BE LE RE RE
Epiphora Y Y Y Y Y Y Y
Dacryocystitis N N N Y Y Y N
Other ocular conditions N N N Blepharitis N Cataract N
Topical eye treatment N Tobramycin N N N N N
Smoking N N N N N N N
Other sinonasal disorders N Chronic rhinitis
Acute sinusitis
N N N N Chronic sinusitis
Other systemic diseases DM N N N N N N
Treatment Conservative RE: EXT-DCR
LE: ENDO-DCR
LE: EXT-DCR
RE: EXT-DCR
RE:
ENDO-DCR
RE: ENDO-DCR*
RE: ENDO-DCR
LE: EXT-DCR
LE: ENDO-DCR RE: ENDO-DCR RE: ENDO-DCR

BE, both eyes; DES, dry eye syndrome; DM, diabetes mellitus; ENDO-DCR, endoscopic dacryocystorhinostomy; EXT-DCR, external dacryocystorhinostomy; F, female; I, first generation; II, second generation; III, third generation; IV, fourth generation; LE, left eye; M, male; N, no; RE, right eye; Y, yes.

* Repeat procedure at different times after failure and return of epiphora.
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2024 January; 15(1): e0005. ISSN: 2076-9172
Published online 2024 January 19. doi: 10.5041/RMMJ.10519.