Table 2.

Family B: Demographics and Medical History of Affected Individuals.

Parameter Subject Number
II1 II2 II3 III1* III2* III3* III4* III5
Sex F F F M F F M F
Age at onset 36 yr 16 yr 5 yr 6 mo 6 mo 1 yr 6 mo 4 yr
Eye involved RE BE RE BE RE LE BE RE
Epiphora Y Y Y Y Y Y Y Y
Dacryocystitis N Y N N N N N N
Other ocular conditions N N N N N N N N
Topical eye treatment Ofloxacin Dexamethasone Ofloxacin Dexamethasone N N N N N N
Smoking N N N N N N N N
Other sinonasal disorders N N N N N N N N
Other systemic diseases N N N N N N N N
Treatment LE:ENDO-DCR LE:ENDO-DCR Conservative N N N N N
Comments N N Down syndrome, CNLDO Epiphora, CNLDO* Epiphora, CNLDO* Epiphora, CNLDO* Epiphora, CNLDO* Epiphora, CNLDO

BE, both eyes; CNLDO, congenital nasolacrimal duct obstruction; DES, dry eye syndrome; DM, diabetes mellitus; ENDO-DCR, endoscopic dacryocystorhinostomy; F, female; II, second generation; III, third generation; LE, left eye; M, male; mo, month; N, no; RE, right eye; Y, yes; yr, year.

* Reported by parents, spontaneous resolution noted with age.
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2024 January; 15(1): e0005. ISSN: 2076-9172
Published online 2024 January 19. doi: 10.5041/RMMJ.10519.