Table 3.

Selection of Imaging Modalities in Non-odontogenic Orofacial and Jaw Pain.

Clinical Presentation or Suspected Condition Initial Imaging? Relevant Modalities Key Points
General screening across diagnostic categories Consider after assessment Panoramic radiography Broad survey of teeth, jaws, and gross TMJ; targeted imaging may still be needed
Typical masticatory myalgia or uncomplicated pain-related TMD Usually no None initially Image for trauma, atypical or progressive signs, or non-response
TMJ internal derangement: painful clicking, locking, or persistent restriction Usually no initially TMJ MRI (open/closed mouth) For persistent locking, uncertainty, or planned intervention
TMJ osteoarthritis or ankylosis Yes if suspected CBCT/CT ± MRI CT for bone; MRI for inflammation or soft-tissue ankylosis
Progressive asymmetry, deviation, occlusal change, or skeletal lesion Yes Cephalometric radiographs; CBCT/CT; SPECT selectively Define deformity or mass; SPECT may assess active bone growth
Eagle syndrome Usually yes Thin-section CT ± 3D Imaging must correlate with the pain pattern
Space-occupying or infiltrative lesion Yes; expedite if progressive Contrast MRI ± CT/CBCT MRI for soft tissue and nerves; CT for bone
Septic arthritis of the TMJ Urgent Contrast CT/MRI; joint aspiration Do not delay antibiotics or drainage
Uncomplicated acute maxillary sinusitis Usually no Sinus CT selectively For persistent, recurrent, complicated, or odontogenic disease
Deep facial or cervical space infection Urgent Contrast CT; MRI selectively Airway and treatment take priority
Meal-related gland pain/swelling or salivary obstruction Often US; non-contrast or contrast CT US for gland; CT for stones, abscess, or tumor
New-onset trigeminal neuralgia Generally yes High-resolution brain/trigeminal MRI Assess compression and secondary causes
Progressive sensory loss, numb chin syndrome, or perineural spread Urgent Contrast MRI ± CT Image the full nerve course; CT adds bone detail
Post-traumatic or iatrogenic trigeminal neuropathy Selective CBCT/CT ± MR neurography Seek a reversible compressive cause
Stable orofacial migraine or primary headache Usually no CT/MRI only with red flags Image red flags, not pain intensity
Persistent idiopathic facial/dentoalveolar pain, BMS, or nociplastic pain No routine imaging Targeted imaging only Avoid repeat imaging without new objective signs
Inflammatory TMJ arthritis Often MRI ± CBCT/CT MRI for active disease; CT for chronic damage
Giant cell arteritis Supportive Temporal/axillary artery US Do not delay corticosteroids when suspicion is high
Carotid or vertebral artery dissection Immediate CTA or MRA ± brain MRI Urgent stroke pathway
Thoracic source or Pancoast tumor If suspected Contrast chest CT ± MRI With arm/shoulder symptoms, Horner syndrome, or weight loss

Note: Panoramic radiography is a broad screening survey, not a universal mandatory test. Each exposure should be clinically justified and tailored to the patient.

BMS, burning mouth syndrome; CBCT, cone-beam CT; CT, computed tomography; CTA, CT angiography; MRA, magnetic resonance angiography; MRI, magnetic resonance imaging; SPECT, single-photon emission CT; TMD, temporomandibular disorder; TMJ, temporomandibular joint; US, ultrasonography.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2026; 17(4): e0023. ISSN: 2076-9172
Published online 2026 October 26. doi: 10.5041/RMMJ.10584