Pioneers of Modern Medicine

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2012 July; 3(3): e0019. ISSN: 2076-9172
Published online 2012 July 31. doi: 10.5041/RMMJ.10083

The History of the Wolff–Parkinson–White Syndrome

Melvin M. Scheinman, M.D., Professor of Medicine, Emeritus *

University of California San Francisco, CA, USA

*To whom correspondence should be addressed. E-mail: scheinman@medicine.ucsf.edu

Abstract

While Drs Wolff, Parkinson, and White fully described the syndrome in 1930, prior case reports had described the essentials. Over the ensuing century this syndrome has captivated the interest of anatomists, clinical cardiologists, and cardiac surgeons. Stanley Kent described lateral muscular connections over the atrioventricular (AV) groove which he felt were the normal AV connections. The normal AV connections were, however, clearly described by His and Tawara. True right-sided AV connections were initially described by Wood et al., while Öhnell first described left free wall pathways. David Scherf is thought to be the first to describe our current understanding of the pathogenesis of the WPW syndrome in terms of a re-entrant circuit involving both the AV node–His axis as well as the accessory pathway. This hypothesis was not universally accepted, and many theories were applied to explain the clinical findings. The basics of our understanding were established by the brilliant work of Pick, Langendorf, and Katz who by using careful deductive analysis of ECGs were able to define the basic pathophysiological processes. Subsequently, Wellens and Durrer applied invasive electrical stimulation to the heart in order to confirm the pathophysiological processes.

Sealy and his colleagues at Duke University Medical Center were the first to successfully surgically divide an accessory pathway and ushered in the modern era of therapy for these patients. Morady and Scheinman were the first to successfully ablate an accessory pathway (posteroseptal) using high-energy direct-current shocks. Subsequently Jackman, Kuck, Morady, and a number of groups proved the remarkable safety and efficiency of catheter ablation for pathways in all locations using radiofrequency energy. More recently, Gollob et al. first described the gene responsible for a familial form of WPW. The current ability to cure patients with WPW is due to the splendid contributions of individuals from diverse disciplines throughout the world.

Keywords: Tachycardia, ventricular pre-excitation, Wolff–Parkinson–White syndrome

 

While the eponym Wolff–Parkinson–White (WPW) syndrome is attributed to the landmark article published by the trio in 1930, 1 other isolated case reports of the same entity were previously reported in the literature. 2 , 3 Over the ensuing years this entity has captivated the interest of anatomists, clinical cardiologists, cardiac surgeons, clinical electrophysiologists, and more recently geneticists.

ANATOMIC STUDIES

The story properly begins with the elucidation of the specialized conduction system of the heart. It was long appreciated that electrical connections bridged the atrial and ventricular chambers. 4 , 5 Stanley Kent in 1893 described lateral atrioventricular (AV) connections and thought these constituted the normal specialized AV conduction system. 6 This work proved controversial and was, in fact, rejected by such notables as Sir Thomas Lewis and Keith Flack. In a later study Dr. Kent described lateral connections with node-like structures which he felt constituted the normal AV conduction system. 7

The work of His 8 and Tawara 9 clearly established the anatomy of the AV node and His–Purkinje system. Moreover, they proved that section of the His bundle resulted in complete AV block and described the His–Purkinje system.

It was clearly Wood et al. 10 who first described the presence of a right-sided accessory pathway (AP) in a patient with an ECG pattern of pre-excitation and Öhnell who described left-sided APs in patients with pre-excitation. 11 Other pioneer observations include those of Mahaim and Benatt who described connections between the AV node or His bundle to fascicles on ventricular myocardium. 12

In an important study, Lev and Lerner 13 presented a detailed investigation of 33 fetal and neonatal hearts and found no evidence for any lateral AV communications. They interpreted Kent’s finding of nodal tissue as being really atrial tissue: in neonates there is sparse collagen in the AV groove, and, depending on the angle of the sections, these may be misinterpreted as AV connections. It is, therefore, surprising that the eponym “Kent” bundle is still used to describe abnormal AV connections.

CLINICAL AND INVASIVE ENDOCARDIAL STUDIES

Drs Wolff, Parkinson, and White are correctly credited with describing the entity that bears their names. Their article was published in the American Heart Journal in August 1930. 1 They described 11 patients with short P-R and bundle branch block, who also suffered with paroxysmal supraventricular tachycardia (SVT) and/or atrial fibrillation (AF).

None of these patients had any evidence of structural cardiac disease, and the investigators confirmed (actually had reported previously) that administration of atropine would serve to normalize AV conduction with disappearance of the “bundle branch block” pattern (Figure 1). The authors felt that the entity was “neurogenic” in origin and was of little clinical consequence.

Figure 1 Figure 1
Simultaneous recording of three-lead ECG obtained from the original article by Drs Wolff, Parkinson, and White. 1 (Reproduced with permission from Elsevier.)

It was only later that Mines 14 demonstrated that the concept of circus movement tachycardia was as a mechanism of tachycardia. According to T.N. James, 15 it was Holzmann and Scherf 16 in 1952 who were the first to describe pre-excitation as being due to antegrade conduction over an accessory AV connection.

The incredible contributions of Pick, Langendorf, and Katz deserve mention. 17 19 They undertook detailed and painstaking analyses of literally thousands of strips from patients with the WPW syndrome and concluded that the arrhythmias were due to differences in conduction properties between the AV node and the AP, which allowed for initiation of SVT by premature beats. Remarkably they described concealed conduction into the pathway and the relationship between SVT and AF for these patients. Much of their pioneering observations were substantiated by intracardiac studies.

Drs Durrer and Wellens 20 , 21 were the first to systematically use programmed electrical studies in numbers to clearly define the tachycardia mechanisms in patients with WPW. They showed that premature cardiac stimulation could induce orthodromic (SVT) (antegrade conduction over the AV node, retrograde conduction over the AP) as well as antidromic tachycardias (antegrade conduction over the AP, retrograde conduction over the node). These observations and others 22 , 23 provided the framework for the use of intracardiac studies to define AP location and physiology.

SURGICAL CONTRIBUTIONS

Prior to the current era of catheter ablation, patients with SVT intractable to drug therapy were treated with surgical dissection of the AV junction. 24 , 25 This approach was largely used for management of the patient with atrial fibrillation refractory to drug therapy but would not be appropriate for those with APs since extirpation of the AV junction would not mitigate against rapid conduction over an AP. Durrer and Roos 26 performed intraoperative mapping and cooling (in an important proof of concept experiment) to locate and transiently prevent conduction in a patient with a right-sided AP. Subsequently Burchell et al. 27 used intraoperative mapping and abolished pre-excitation with a local injection of procainamide. A limited surgical incision over this area resulted in only transient loss of pre-excitation. Sealy et al. 28 were the first to successfully ablate an AP in a human. The Duke team initially used an epicardial approach but subsequently showed that APs in all locations (both free wall and septal) could be successfully ablated using an endocardial technique. 29 Only later was a cryo-epicardial technique used by Guiraudon et al. 30

CATHETER ABLATION

The technique of catheter ablation of the AV junction was introduced by Scheinman et al. in 1981. 31 The technique involved use of high-energy direct-current shocks delivered to the region of the AV junction. This was followed by attempts to use catheter techniques for ablation of APs in various locations. In 1984 Fisher et al. 32 used this technique for attempted ablation of left-sided APs via the coronary sinus. This technique was abandoned due to limited efficacy and risk of cardiac tamponade. In 1984 Morady and Scheinman 33 reported a catheter technique for right posteroseptal APs associated with a 65% efficacy without cardiac tamponade as the shock was delivered just outside the os of the coronary sinus. In addition Warin et al. described successful catheter ablation of free wall APs using high-energy D/C shock. 34

The subsequent introduction of radiofrequency energy for catheter ablation 35 completely revolutionized our approach to the management of patients with WPW (Figure 2). Use of radiofrequency energy, as well as improved mapping and catheter design, has had a dramatic impact on patient management. The remarkable work particularly of Jackman et al. introduced techniques of both recording and ablation of AP potentials. 36 The modern era of widespread use of radiofrequency ablation for patients with AP-mediated tachycardia was documented by the pioneering efforts of several groups. 36 38 Moreover, the efficacy and safety of these procedures have been documented by registry and prospective studies. 39 , 40

Figure 2 Figure 2
Schema showing use of catheter technique for ablation of a right free wall accessory pathway.

FUTURE DIRECTIONS

Catheter ablative procedures have become the method of choice for care of patients with the WPW syndrome. While incremental improvements in catheter design or mapping systems will undoubtedly facilitate ablative procedures, the major advances appear to reside in the area of molecular genetics and biology. Mehdirad et al. 41 described an autosomal dominant form of WPW associated with cardiomyopathy and progressive cardiac conduction system disease linked to chromosome 7q3. Subsequently Gollob et al. 42 identified a missense mutation in the gene that encodes the gamma-2 regulatory subunit of AMP-activated protein kinase which was associated with the WPW syndrome in two families. These families were characterized as having cardiomyopathy, atrial fibrillation, multiple APs, and a poor prognosis. Protein kinase is involved in the phosphorylation of multiple metabolic pathways including energy substrate regulation. The genetic abnormality has been associated with cardiac glycogen storage disease. 43

Further studies have defined the role of epicardial derived cells in the formation of the AV groove. 44 Conceivably, defects in function of these primitive cells act as progenitor for residual muscle connections between atrium and ventricle. More recently studies involving activation of notch signaling provided fully penetrant APs as well as ventricular pre-excitation in the developing mouse heart. 45 Alternatively, inhibition of notch signaling leads to a hypoplastic AV node with loss of slowly conducting cells.

CONCLUSION

The current history of the WPW syndrome results in a happy situation where a curative procedure is available for the majority of our patients. This situation arose from the brilliant collaborative work of anatomists and clinicians who described the syndrome, as well as surgeons and cardiac electrophysiologists. Further advances in understanding the precise pathogenesis of this disorder belong to the molecular biologists.

Acknowledgments

Dr. Scheinman would like to acknowledge research grant support from the Deb Foundation Grant.

Abbreviations:

AF atrial fibrillation;
AP accessory pathway;
AV atrioventricular;
SVT supraventricular tachycardia;
WPW Wolff-Parkinson-White.

Footnotes

Conflict of interest: No potential conflict of interest relevant to this article was reported.

REFERENCES
1.
Wolff L, Parkinson J, White PD. Bundle-branch block with short P-R interval in healthy young people prone to paroxysmal tachycardia. Am Heart J. 1930;5:685–704. http://dx.doi.org/10.1016/S0002-8703(30)90086-5 .
2.
Wilson FN. A case in which the vagus influenced the form of the ventricular complex of the electrocardiogram. Arch Intern Med. 1915;16:1008–27. http://dx.doi.org/10.1001/archinte.1915.00080060120009 .
3.
Wedd AM. Paroxysmal tachycardia, with reference to nomotropic tachycardia and the role of the extrinsic cardiac nerves. Arch Intern Med. 1921;27:571–90. http://dx.doi.org/10.1001/archinte.1921.00100110056003 .
4.
Paladino G. Contribuzione all anatomia, istologia e fisiologia del cuore. Movemento Napoli. 1876;8:428.
5.
Gaskell WH. On the innervation of the heart. With especial reference to the heart of the tortoise. J Physiol. 1883–1884;4:43.
6.
Kent AFS. Researches on the structure and function of the mammalian heart. J Physiol. 1893;14:233.
7.
Kent AFS. A conducting path between the right auricle and the external wall of the right ventricle in the heart of the mammal. J Physiol. 1914;48:57.
8.
His W. Die Thatigkeit des embryonalen Herzens und deren Bedeutung fur die Lehre von der Herzbewegung beim Erwachsenen. Med Klinik in Leipzig. 1893;I:14.
9.
Tawara, S. Des reizleitungsystem des Saugetierherzens. Eine anatomischhistologische Studie uder das atrio-ventrikularbundle und die Purkinjeschen faden. Jena, Germany: Verlag von Gustav Fischer; 1906. p. 200.
10.
Wood FC, Wolferth CC, Geckeler GD. Histologic demonstration of accessory muscular connections between auricle and ventricle in a case of short P-R interval and prolonged QRS complex. Am Heart J. 1943;25:454–62. http://dx.doi.org/10.1016/S0002-8703(43)90484-3 .
11.
Öhnell RF. Pre-excitation, cardiac abnormality, pathophysiological, patho-anatomical and clinical studies of excitatory spread phenomenon bearing upon the problem of the WPW (Wolff, Parkinson, and White) electrocardiogram and paroxysmal tachycardia. Acta Med Scand. 1944;152:1–167.
12.
Mahaim I, Benatt A. Nouvelles recherches sur les connexions superieures de la branche gauche du faisceau de His-Tawara avec la cloison interventriculaire. Cardiologia. 1937;1:61–73. http://dx.doi.org/10.1159/000164567 .
13.
Lev M, Lerner R. The theory of Kent. A histologic study of the normal atrioventricular communications of the human heart. Circulation. 1955;12:176–84. http://dx.doi.org/10.1161/01.CIR.12.2.176 .
14.
Mines GR. On circulating excitations in heart muscles and their possible relationship to tachycardia and fibrillation. Proc Trans R Soc Can. 1914;8:43–52.
15.
James TN. The Wolff-Parkinson-White syndrome: evolving concepts of its pathogenesis. Prog Cardiovasc Dis. 1970;13:159–89. http://dx.doi.org/10.1016/0033-0620(70)90007-1 .
16.
Holzmann M, Scherf D. Uber elektrokardiogramme mit verkurzter Vorhof-Kammer Distanz und positiven P. Zacken Z Klin Med. 1932;121:404–10.
17.
Pick A, Katz LN. Disturbances of impulse formation and conduction in the pre-excitation (WPW) syndrome—their bearing on its mechanism. Am J Med. 1955;19:759–72. http://dx.doi.org/10.1016/S0002-9343(55)80021-6 .
18.
Pick A, Langendorf R. Recent advances in the differential diagnosis of A-V junctional arrhythmias. Am Heart J. 1968;76:553–75. http://dx.doi.org/10.1016/0002-8703(68)90143-9 .
19.
Katz, LN.; Pick, A. Clinical electrocardiography: Part I The arrhythmias: with an atlas of electrocardiograms. Philadelphia: Lea & Febiger; 1956. pp. 43pp. 679–708.
20.
Durrer D, Schoo L, Schuilenburg RM, Wellens HJ. The role of premature beats in the initiation and the termination of supraventricular tachycardia in the Wolff-Parkinson-White syndrome. Circulation. 1967;36:644–62. http://dx.doi.org/10.1161/01.CIR.36.5.644 .
21.
Wellens HJ, Schuilenburg RM, Durrer D. Electrical stimulation of the heart in patients with Wolff-Parkinson-White syndrome, type A. Circulation. 1971;43:99–114. http://dx.doi.org/10.1161/01.CIR.43.1.99 .
22.
German LD, Gallagher JJ. Functional properties of accessory atrioventricular pathways in Wolff-Parkinson-White syndrome. Clinical implications. Am J Med. 1984;76:1079–86. http://dx.doi.org/10.1016/0002-9343(84)90862-3 .
23.
Gallagher JJ, Sealy WC, Kasell J, Wallace AG. Multiple accessory pathways in patients with the pre-excitation syndrome. Circulation. 1976;54:571–91. http://dx.doi.org/10.1161/01.CIR.54.4.571 .
24.
Dreifus LS, Nichols H, Morse D, Watanabe Y, Truex R. Control of recurrent tachycardia of Wolff-Parkinson-White syndrome by surgical ligature of the A-V bundle. Circulation. 1968;38:1030–36. http://dx.doi.org/10.1161/01.CIR.38.6.1030 .
25.
Edmunds JH, Ellison RG, Crews TL. Surgically induced atrio-ventricular block as treatment for recurrent atrial tachycardia in Wolff-Parkinson-White syndrome. Circulation. 1969;39(suppl 1):105–11.
26.
Durrer D, Roos JP. Epicardial excitation of ventricles in patient with Wolff-Parkinson-White syndrome (type B). Circulation. 1967;35:15–21. http://dx.doi.org/10.1161/01.CIR.35.1.15 .
27.
Burchell HB, Frye RL, Anderson MW, McGoon DC. Atrioventricular and ventriculoatrial excitation in Wolff-Parkinson-White syndrome (type B). Circulation. 1967;36:663–69. http://dx.doi.org/10.1161/01.CIR.36.5.663 .
28.
Cobb FR, Blumenschein SD, Sealy WC, Boineau JP, Wagner GS, Wallace AG. Successful surgical interruption of the bundle of Kent in a patient with Wolff-Parkinson-White syndrome. Circulation. 1968;38:1018–29. http://dx.doi.org/10.1161/01.CIR.38.6.1018 .
29.
Cox JL. NASPE history: cardiac surgery for arrhythmias. Pacing Clin Electrophysiol. 2004;27:266–82. http://dx.doi.org/10.1111/j.1540-8159.2004.00426.x .
30.
Guiraudon GM, Klein GJ, Sharma AD, Yee R, McLennan DG. Surgery for the Wolff-Parkinson-White syndrome: the epicardial approach. Semin Thorac Cardiovasc Surg. 1989;1:21–33.
31.
Scheinman MM, Morady F, Hess DS, Gonzalez R. Catheter-induced ablation of the atrioventricular junction to control refractory supraventricular arrhythmias. JAMA. 1982;248:851–5. http://dx.doi.org/10.1001/jama.1982.03330070039027 .
32.
Fisher JD, Brodman R, Kim SG, et al. Attempted nonsurgical electrical ablation of accessory pathways via the coronary sinus in the Wolff-Parkinson-White syndrome. J Amer Coll Cardiol. 1984;4:685–94. http://dx.doi.org/10.1016/S0735-1097(84)80394-0 .
33.
Morady F, Scheinman MM. Transvenous catheter ablation of a posteroseptal accessory pathway in a patient with the Wolff-Parkinson-White syndrome. N Engl J Med. 1984;310:705–7. http://dx.doi.org/10.1056/NEJM198403153101108 .
34.
Warin JF, Haissaguerre M, Lemetayer P, Guillem JP, Blanchot P. Catheter ablation of accessory pathways with a direct approach. Results in 35 patients. Circulation. 1988;78:800–15. http://dx.doi.org/10.1161/01.CIR.78.4.800 .
35.
Borggrefe M, Budde T, Podczeck A, Breithardt G. High frequency alternating current ablation of an accessory pathway in humans. J Am Coll Cardiol. 1987;10:576–82. http://dx.doi.org/10.1016/S0735-1097(87)80200-0 .
36.
Jackman WM, Wang XZ, Friday KJ, et al. Catheter ablation of accessory atrioventricular pathways (Wolff-Parkinson-White syndrome) by radiofrequency current. N Engl J Med. 1991;334:1605–11. http://dx.doi.org/10.1056/NEJM199106063242301 .
37.
Kuck KH, Schlüter M, Geiger M, Siebels J, Duckeck W. Radiofrequency current catheter ablation of accessory atrioventricular pathways. Lancet. 1991;337:1557–61. http://dx.doi.org/10.1016/0140-6736(91)93258-B .
38.
Calkins H, Sousa J, el Atassi R, et al. Diagnosis and cure of the Wolff-Parkinson-White syndrome or paroxysmal supraventricular tachycardias during a single electrophysiologic test. N Engl J Med. 1991;324:1612–18. http://dx.doi.org/10.1056/NEJM199106063242302 .
39.
Scheinman MM. NASPE survey on catheter ablation. Pacing Clin Electrophysiol. 1995;18:1474–8. http://dx.doi.org/10.1111/j.1540-8159.1995.tb06733.x .
40.
Hindricks G, for the Multicentre European Radiofrequency Survey (MERFS) investigators of the Work Group on Arrhythmias of the European Society of Cardiology. The Multicentre European radiofrequency survey (MERFS): complications of radiofrequency catheter ablation of arrhythmias. Eur Heart J. 1993;14:1644–53. http://dx.doi.org/10.1093/eurheartj/14.12.1644 .
41.
Mehdirad AA, Fatkin D, DiMarco JP, et al. Electrophysiologic characteristics of accessory atrioventricular connections in an inherited form of Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol. 1999;10:629–35. http://dx.doi.org/10.1111/j.1540-8167.1999.tb00239.x .
42.
Gollob MH, Green MS, Tang AS, et al. Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med. 2001;344:1823–31. http://dx.doi.org/10.1056/NEJM200106143442403 .
43.
Wolf CM, Arad M, Ahmad F, et al. Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations. Circulation. 2008;117:144–54. http://dx.doi.org/10.1161/CIRCULATIONAHA.107.726752 .
44.
Gittenberger-de Groot AC, Vrancken Peeters MP, Mentink MM, Gourdie RG, Poelmann RE. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circ Res. 1998;82:1043–52. http://dx.doi.org/10.1161/01.RES.82.10.1043 .
45.
Rentschler S, Harris BS, Kuznekoff L, et al. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J Clin Invest. 2011;121:525–33. http://dx.doi.org/10.1172/JCI44470 .