New Insights in Clinical Medicine

Hunger Whilst "In Utero" Programming Adult Osteoporosis

George M. Weisz and William R. Albury


The fetal “programming of adult diseases” has been previously reviewed. The descriptions were comprehensive, dealing with the effects of nutritional deprivation on the development of adult metabolic and cardiovascular diseases. During the past decade, research into this “programming” also expanded to the development of osteoporosis. The present review deals with the imbalance of bone mineral metabolism, “programmed” by maternal/fetal/infantile nutritional deprivation, and is illustrated with a family history from the Budapest Ghetto.

Rambam Maimonides Med J 2014;5(1):e0004