Letters to the Editor

Response to Letter to the Editor: Prospective Validation of PaDd—A Roadmap

Ramon Cohen and Daniel Elbirt

Abstract

To the Editor,

We thank Dr Vijayasimha and colleagues for their thoughtful analysis of our work and their proposal for prospective validation of the Padua × D-dimer (PaDd) score. Their roadmap provides a rigorous framework that addresses critical gaps in our single-center retrospective design. We welcome this opportunity to clarify key methodological considerations and invite the global research community to collaborate on next-generation studies.

Rambam Maimonides Med J 2026;17(1):e0010